Abstract: Esophageal Dysmotility In Children
Breast-Fed By Mothers With Silicone Breast Implants:
Long Term Follow-Up And Response to Treatment.

Authors: Levine, Ilowite Schneider Children's Hospital

Abstract: We have previously reported a characteristic scleroderma-like eophogeal dysmotility pattern(decreased LES pressure and decreased % propogation)in some children breast fed by mothers with silicone iplants(CBFSI). In order to determine the natural history of this disorder and its response to treatment,we reevaluated 9 of 16 children (7 boys,2 girls; age 3-12 yrs.) with esophogeal manometry,at a mean of 2.0 yrs.(range 1.3-3.3) after the initial study. In 6 of the 9 patients who had repeat esophogeal manometric studies, intravenous metoclopramide was administered(0.1 mg/kg) and manometry repeated. Results are expressed as means +sds,=p<0.5(paired t test). The esophogeal dysmotility in CBFSI appears to be chronic over 2 yrs.of follow up, indicating persistent dysfunction in the autonomic nervous system. response to metoclopramide, especially with regards to % propagation and amplitude appears to be good,suggesting that this agent may be useful in the treatment of the esophogeal dysfunction.